Lucy Simian/Relationships

Nicole Watterson
In the episode "The Ape", it is confirmed that Miss Simian used to call Nicole a loser, thus causing Nicole and Miss Simian to show dislike towards each other.

Gumball Watterson
As one of the students in her class, Miss Simian is forced to teach him but generally has a love-hate relationship regarding him. On one hand she can't stand his misbehaving and generally seems to point him out as the source of many problems in the class. However, in episodes such as "The Ape" and "The Apology", she does show some respect for him and at least doesn't mind having his assistance even if it's for her own self-advancement.

Principal Brown
Principal Brown is in love with Miss Simian, as seen in The Sock and it is strongly hinted that she is in love with him too.