Nicole Watterson/Relationships

Gumball
Nicole loves her son very much, and has been willing to go to great lengths to protect him. She is aware that he's not the most popular at school, so she often gives him advice or physically tries to help him, whether it be going to school with him or confronting his bully. Gumball's idiocy creates problems for her but she's willing to forgive him in the end, only after she screams, of course.

Darwin
Oddly enough she doesn't interact with Darwin that much. In the show, she rarely speaks to him one-on-one. However it she has shown her care for him in "The Genius", when she got angry about the Government taking Darwin away. Also in the "The Gi", she did fear Darwin would follow down the same path with Gumball. So despite her lack of motherly talk with Darwin, she does in fact love him.

Anais
Nicole treats Anais on a higher standard then she treats Gumball and Darwin. Well aware that she's smarter than her brothers, Nicole tries her hardest to make sure Anais's intelligence stays intact. Often she advises not to engage with her brothers in dangerous things, and scolded Anais at the end of "The Goons" even worse than her brothers. But she loves her daughter, and was willing to change the entire family in order to make sure she is okay.

Richard
Nicole's love for Richard is rather odd, but still there. She's aware that Richard is socially awkward and still has memories of him being an idiot. But that doesn't stop her from protecting him with all her might, and taking care of him as well.